March 19,2023

TOG Article: Human papillomavirus-independent cervical cancer and its precursor lesions

Key content

  • With the move towards ubiquitous human papillomavirus (HPV) primary screening and increasing coverage with HPV vaccination, the prevalence of HPV-associated cervical cancers is predicted to decrease.
  • Clinicians must be aware of HPV-independent adenocarcinomas, which are likely to increase as a proportion of the total diagnosed cervical adenocarcinomas.
  • Advances in histopathology, immunohistochemistry and molecular genetics have increased our understanding of the spectrum of gastric-type and other rare HPV-independent adenocarcinomas.
  • Clinical outcome and prognosis of HPV-independent adenocarcinoma is worse than the HPV-associated adenocarcinoma.
  • There is a paucity of evidence-based guidelines tailored to management of HPV-independent adenocarcinomas.